Measuring Concordance of Subtype Sulcogryral Patterns in Monozygotic and Dizygotic Twin Pairs
Shane Kozick ’23
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The brain’s surface is made up of sulci (grooves) and gyri (ridges) that together create the distinct folded (sulcogryal) appearance of the brain. It is known that individual differences in the sulcogyral pattern of the orbital frontal cortex (OFC) can lead to variation in social behaviors and psychiatric pathology. Recent research has focused on the sulcogyral folding pattern variations in individuals, specifically within the OFC. Four pattern types have been identified based on the continuity of four distinct sulci, and subtypes within each pattern type have been defined that offer more fine-grained characterization of OFC structure. To date, there have been no analyses of OFC sulcogyral patterns (or subpatterns) and genetic associations. The goal of this project is to categorize the OFC pattern subtypes of monozygotic (MZ) and dizygotic (DZ) twin pairs to explore whether the development of OFC pattern types have a strong genetic component. The study is accomplished using a publicly available structural MRI data set from the Human Connectome Project (HCP). We used neuroimaging software to individually subtype 570 subjects in the data set and we are currently investigating the association with genetics.